Generic Acomplia: One Drug versus two Sicknesses

 

In today’s lifestyle, almost everything is fast and automatic like fast cash, fast communication, fast foods and many others. This is advantageous to people in many ways but the by product of this lifestyle is overweight and obesity. This is true to all people young and old. As you go walking on the street or riding on the car going to work or school everyday, how many fat persons have you seen?

 

 Countless people are overweight because of the kind of foods they eat. Maost fast foods are rich in carbohydrates, fats and preservatives that are harmful to our body. As per survey conducted by World Health Organization, a huge percentage of people suffer from type 2 diabetes, high blood pressure and kidney failure were due to improper foods that they eat.

The discovery of Rimonabant also known as Generic Acomplia is really in time to today’s condition. Generic Acomplia is an anoretic antiobesity drug that works not to reduce your body weight but on controlling the craving of foods as well as other detrimental urges like smoking.

 

Truly this Generic Acomplia is so beneficial because it can remedy two sicknesses at the same time. Smoking is the prime cause of lung cancer but even though people know it can harm their body yet they cannot control their desire to smoke. This is where Generic Acomplia takes an important role. Generic Acomplia acts as a blocker in the brain that switches off the brain circuits hence a person will not feel hungry for foods or cigarettes. In clinical test conducted, it was found out that after a regular dose of Generic Acomplia as a daily supplement smoker quits smoking.

 

The benefits of generic acomplia did not stop in obesity and smoking. It was found out that it can also prevent the risk of cardiovascular disease. You might be thinking that if you start taking this supplement your weight will reduce automatically; well unfortunately this is not what you are thinking of. A proper balance diet with a daily exercise is another requirement for this Generic Acomplia to work successfully.

 

Who can take Generic Acomplia (Rimonabant)?

Generic Acomplia is highly recommended to obese or overweight persons who are suffering from type 2 diabetes mellitus and those smokers who wanted to quit smoking. The most proper way to know if you can take this drug is to consult your doctor.

 

Where can you buy Generic Acomplia ( Rimonabant)?

Generic Acomplia can be purchase in some leading online pharmacy. Its affordable price is for everybody’s reach. No need for you to go out of your home to purchase this wonderful product because it can be done in one click. Visit some online pharmacy and read about their promos and discounts.

 

Do not let your bad eating habits affects your entire existence. Start working on regulating your body weight by doing daily physical activities, eating the right kind of foods and taking Generic Acomplia as your daily supplement.


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Kamagra (Generic Viagra) [sildenafil citrate], manufactured by Ajanta Pharma, Ltd, this drug is the first cyclic guanosine monophosphate [cGMP] specific phosphodiesterase type 5 enzyme inhibitor. This enzyme helps in regulating the blood circulation in the penile tissue. This leads to better penile erection.

Kamagra (Generic Viagra) is primarily indicated in the treatment of impotence [erectile dysfunction]

 

The compound sildenafil was synthesized in Pfizer’s research lab in Kent, England. Believe it or not, sildenafil was actually being studied for the treatment of hypertension and angina pectoris. Angina pectoris, or chest pain, caused by an insufficient supply of oxygen and decreased blood flow to the heart muscle. Angina is frequently the first sign of ischemic heart disease. However, during the phase 1 clinical trials, it was found that instead of having a remarkable action on angina, this drug was very effective in inducing penile erections, the main pathology behind erectile dysfunction.

The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first oral treatment approved to treat erectile dysfunction in the United States

Needless to say, this drug has become a household hit.

 

Erectile dysfunction:

Erectile dysfunction (ED) is defined as the inability of a man to achieve or maintain an erection sufficient for his sexual needs or the needs of his partner

Erection of the penis during coitus or otherwise is a result of increase in the blood flow of the arteries of the penis and simultaneous relaxation of the smooth muscle of corpora cavernosum. This whole process is due to the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP in turn, relaxes smooth muscle and resulting in an increase in the blood flow to the corpus cavernosum.

In erectile dysfunction, enough blood does not flow in the arteries of the penis to cause a sufficient erection.

Causes of erectile dysfunction:

With reduced libido:

-          hypogonadism

-          depression

With intact libido:

-          psychological problems, including anxiety

-          vascular insufficiency [atheroma]

-          neuropathic [diabetes mellitus, alcohol excess, multiple sclerosis]

-          drugs [beta blockers, thiazide diuretics]

An organic cause can be found out in about 50% of the cases of erectile dysfunction; the rest are either psychogenic in origin or are due to a psychiatric illness such as depression which requires appropriate drug treatment. Systemic diseases like chronic liver or kidney diseases and drug addiction are important causes and should be looked for. In case of any psychogenic problem, even the partner should be actively involved in the counseling therapy

The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum of the penile tissue during sexual stimulation. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Kamagra (Generic Viagra) [sildenafil citrate] has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

There are many types of PDE, each having varied function. The plus point of Kamagra (Generic Viagra) [sildenafil citrate] is that it is PDE 5 selective, though it can also act on the other types of PDE. In fact higher doses or plasma levels of the drug is thought to be associated with defects in color vision due to its action on PDE 6.Kamagra (Generic Viagra) [sildenafil citrate] has a 4,000-fold selectivity for PDE5 versus PDE3, which is concerned with cardiac contractility.

 

Indications:

-          Erectile dysfunction. This is the main indication whereas for the indications given below, sildenafil is not in the first line treatment regimen.

-          pulmonary arterial hypertension

-          prevention of high altitude pulmonary edema associated with altitude sickness

-          treatment of benign prostatic hypertrophy [BPH]-associated lower urinary tract symptoms [LUTS]

Indications under investigation:

-          Relieving female sexual dysfunction. Several studies have indicated the drug may be effective in improving libido and arousal in women taking selective serotonin uptake inhibitors (SSRIs)

-          Treatment of infertility. Women who have had repeated failures with in vitro fertilization (IVF) due to poor development of the endometrium [tissue that lines the uterus] may benefit from treatment with vaginal suppositories containing sildenafil.

-          Esophageal motility dysfunction (achalasia), since it can enhance nitric oxide production.

 

Contraindications:

 -  patients on nitric oxide drugs since sildenafil potentiate the hypotensive effects of  nitrates, and its administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is therefore contraindicated.

 - There is a degree of cardiac risk associated with sexual activity, especially in elderly people above the age of 60 years. There is increase incidence of mortality and morbidity with KAMAGRA (GENERIC VIAGRA) [sildenafil]

    - Severe hepatic impairment (decreased liver function)

    - Severe impairment in renal function

    - Hypotension (low blood pressure)

    - History of stroke or heart attack

    - Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases)

Side effects:

The most commonly reported side effects of KAMAGRA (GENERIC VIAGRA) are headache, flushing of the face, upset stomach, and nasal congestion.

Other less common side effects include, but are not limited to:

• vision problems, including sensitivity to light, blurred vision, and a color tinge to vision
• urinary tract infection
• diarrhea
• dizziness
• rash

Dosage:

Administered in the dose of 50 mg one hour before the intended sexual activity. Based on effectiveness and toleration, it can be increased to 100 mg or decreased to 25 mg.

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Acomplia (Rimonabant), marketed by Sanofi-Aventis is a selective CB1 endocannabinoid receptor antagonist indicated for the treatment of obesity.

Its mechanism of action is to block the endogenous cannabinoid binding to neuronal CB1 receptors.

 

What is endocannabinoid system?

The endocannabinoid system is in the part of the brain that regulates metabolism, energy levels and appetite.

With reference to the above drug, endocannabinoid receptors on activation will increase the appetite. Hence, drugs like Acomplia (Rimonabant) will block this endocannabinoid receptor, eventually leading to a decrease in the appetite. It is the most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction

 

So what is obesity?

Obesity medically is defined on the basis of Body Mass Index which is the individual's body weight divided by the square of their height in kg/m². So, a BMI of 18.5 to 25 may indicate optimal weight; a BMI lower than 18.5 suggests the person is underweight while a number above 25 may indicate the person is overweight; a BMI below 17.5 may indicate the person has anorexia or a related disorder; a number above 30 suggests the person is obese (over 40, morbidly obese).

So technically speaking, those with their body mass index of 30 and above tend to fall in the high risk zone. It arises from the accumulation of excess fat in the body from over consumption of fatty foods and is now one of the most common nutritional disorders in the world.

Latest studies have corroborated the fact that obesity is a silent killer. It is associated with cardiovascular disease, especially angina and myocardial infarction, atherosclerosis and arteriosclerosis leading to cerebrovascular accidents/ strokes.

They also cause joint pains and are also associated with certain cancers like that of the breast or of the colon. The proportion of obese individuals in the developed countries has reached epidemic proportions. To put this picture in a better perspective, statistics show that one in five of all Americans are obese and one in three overweight.

In the presence of diabetes mellitus it forms a deadly combination and is termed as diabetisity. It shows more predilections to Type 2 diabetes mellitus

Various therapeutic strategies have been explored, including:

• Serotonin and nor adrenaline reuptake inhibitors (anorectic agents)
• Lipase inhibitors
• ß 3-adrenoreceptor agonists
• Leptin agonists
• Melanocortin-3 agonists

All these strategies have shown some amount of success.

Usually, after having cannabis these drug addicts suffer from extreme hunger pangs which these smokers refer to as ‘munchies’. This lead to the belief that cannabinoid is associated with hunger pangs and if this receptor is suppressed it will lead to decreased appetite which is what precisely the manufacturers of Acomplia (Rimonabant) Sanofi-Aventis did.

Rimonabant prevents the endogenous cannabinoid binding to CB1 receptors in nerve cells. These CB1 receptors, when activated, stimulate appetite. Hence this drug blocks the activation of these CB1 receptors and thus reduces appetite.

 Side Effects

1.     Nausea and vomiting--Nausea, vomiting and other gastrointestinal disorders were relatively common side effects of taking Acomplia.

2. Disorders of the nervous system-- this category includes headaches, faintness and feeling dizzy.
3. Psychiatric Disorders--Including mood swings, anxiety, depression, irritability, sleep disorders and other similar disorders. The current advice is that you should not take this drug if you suffer from mental health problems. The drug is not suitable for those with continuing major depressive illness and/or antidepressive treatment.

 

Contraindications:

1. Any hypersensitivity to the drug or any of its ingredients.
2. Presence of liver damage.
3. Impaired renal function
4. Age more than 75 years and less than 16 years
5. Pregnant and lactating women.
6. In patients with lactose intolerance since it Acomplia contains lactose
7. It should only be used with caution in combination with CYP3A4 inhibitors, such as ketoconazole, ritonavir, Clarithromycin and related drugs.
8. It is not to be prescribed in patients with untreated psychiatric disease.

Acomplia [Rimonabant] taken for up to two years in conjunction with diet and exercise produces greater weight loss than the placebo, although most of the weight loss occurs in the first year.

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Tadacip [tadalafil], a product of Cipla is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It is used in the treatment of erectile dysfunction [impotence]. Tadacip [tadalafil] has been developed to treat men who do not respond to sildenafil [VIAGRA]. TADACIP does not prevent pregnancy or the spread of sexually transmitted diseases such as syphilis, gonorrhea, human immunodeficiency virus (HIV).

 

Erectile dysfunction

Erectile dysfunction (ED) is defined as the inability of a man to achieve or maintain an erection sufficient for his sexual needs or the needs of his partner

Erection of the penis during coitus or otherwise is a result of increase in the blood flow of the arteries of the penis and simultaneous relaxation of the smooth muscle of corpora cavernosum. This whole process is due to the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP in turn, relaxes smooth muscle and resulting in an increase in the blood flow to the corpus cavernosum.

In erectile dysfunction, enough blood does not flow in the arteries of the penis to cause a sufficient erection.

Causes of erectile dysfunction:

With reduced libido:

hypogonadism

depression

With intact libido:

psychological problems, including anxiety

vascular insufficiency [atheroma]

neuropathic [diabetes mellitus, alcohol excess, multiple sclerosis]

drugs [beta blockers, thiazide diuretics]

In case of any psychogenic problem, even the partner should be actively involved in the counseling therapy.

INDICATION

It is indicated in the treatment of erectile dysfunction.

DOSAGE AND ADMINISTRATION

The recommended starting dose of TADACIP is 10 mg, taken prior to anticipated sexual activity. The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients. The dose should not exceed 20 mg in any circumstances. TADACIP was shown to improve erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal use of TADACIP, this should be taken into consideration. TADACIP may be taken without regards to food, since food does not show any effect on the absorption of the drug. It is important to update the patient on the fact that TADACIP alone does not cause erection of the penis and that self stimulation or with the help of the partner is required.

TADACIP [tadalafil] has a pharmacologic distinction of having a longer half-life of 17.50 hours, meaning it maintains its potency for at least 17.50 hours.   — compared to other drugs of the same class like Viagra (4.0–5.0 hours) and Levitra (4.0–5.0 hours) — resulting in longer duration of action. Due to this unique pharmacological property, TADACIP has earned the sobriquet of "The Weekend Pill"

It is also in the clinical trials for treatment of pulmonary arterial hypertension.

SIDE EFFECTS

Serious side effects:

visual disturbances;

hearing loss, ringing of ears [tinnitus];

chest pain;

irregular heartbeat [arrhythmia];

swelling of hands, feet, ankles;

difficulty in breathing;

seizure (convulsions);

feeling light-headed, fainting; or

Penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

warmth or redness in face, neck, or chest;

stuffy nose, sore throat;

headache;

diarrhea; or

Muscle pain, back pain.

 

CONTRAINDICATIONS

Nitrates [tadalafil can potentiate the hypotensive effect of nitrates]

alpha blockers [a significant augmentation of the blood-pressure-lowering effect of doxazosin]

hypersensitivity

 

OVER DOSAGE

Symptoms of overdose may include:

headache

indigestion or heartburn

flushing

pain in the back, muscles, or any limb

stuffy or runny nose

erection that lasts longer than 4 hours.
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INTRODUCTION

Advancements in the field of science have a tremendous effect in the lifestyle of people around the world. The things which we were only conceiving in our minds a long time ago came into reality after years of research and testing of the greatest minds of every century. The pursuit for the elixir of life has become a race for most developed countries so a lot of them are investing a lot of money, time and effort just to bring quality life in every household around the globe, most especially to those who can afford.

With these evident realities at hand, it is undoubtedly a fact that aside from the prolonging of life span, production of goods which are luxurious and would give immediate satisfaction is also being held as a primary consideration. In medical science, one such thing that has brought so much change in the lifestyle of people is the manufacture of Viagra, a drug that has been popular among people of all ages and races for adding more color to one of the basic needs of humanity---sex.

BRIEF HISTORY

It is safe to remember that Viagra is not for everybody. Originally, Viagra was developed by Pfizer as a drug to help men who were suffering from chest pain. However, sildenafil citrate, the active ingredient of Viagra, as a heart medication did not show progress of attaining its purpose and studies were stopped in 1992. Yet, based on published information about some properties contained in sildenafil citrate, Pfizer researchers began to look at it as a treatment for erectile dysfunction. Erectile dysfunction can also be termed as impotence or the difficulty to have an erection or maintaining it among males. Re-evaluation for its effect on the ability of men with ED to engage in sexual activity, and the ability to achieve and maintain erection sufficient for satisfactory sexual activity was taken.

Later, the clinical trials conducted by the researchers found Viagra to be so effective that the FDA approved it only six months after submission, and without consulting an advisory committee of outside experts because there were no troubling questions and no significant side effects. In furtherance to its primary uses, Viagra is being tested against pulmonary hypertension in children and infertility in women.

 

HOW IT WORKS

Basically Viagra’s appearance is bluish, diamond-shaped tablets with 25mg, 50mg, or 100mg strengths embossed on one side, denoting tablet strength. It works by dilating blood vessels throughout the body, allowing blood to flow more readily to the heart, lungs and other organs. Moreover, Viagra relaxes smooth muscle contractions in the penis. Around 70 percent of men using it reported some improvement in achieving and maintaining an erection. Effects normally begin within 30 minutes and last about 4 hours.

Since Viagra is only for those who have erectile dysfunctions, the drug must be taken orally once a day, one hour before the sexual activity. Viagra is not meant to be taken regularly for a prolonged period. Just take it when you need it.

An important thing to remember also is, you should not take Viagra if you are using nitrate drugs to control angina pain because the combination of the nitrate drugs and Viagra can lower your blood pressure dangerously putting your life in danger. The combinations of drugs are life-threatening for you. If it gives you an allergic reaction, do not use it again. Also, if you have severe heart problems where sexual activity can be a danger to your life, do not take Viagra.

 

AFTER EFFECTS

Side effects of using Viagra include headache, flushed skin, and anxiety. Its serious risks can include distorted vision and priapism -- a painful, prolonged rection that may require medical intervention. Historically, 69 deaths were inked to Viagra during its first three months on the market so the U.S. Food nd Drug Administration issued a warning against using it with amyl nitrate "poppers"), nitroglycerin, and nitrous oxide since each dilates blood vessels, hus, a dangerous drop in blood pressure can result, leading to possible heart attack or stroke.

ADDICTIVE?

Probably yes. Firstly, men who take Viagra to obtain even greater pleasure from their sex life become so much used to the drug that they find their love life uninteresting without the use of Viagra, as compared to earlier. Secondly, to some men, the effect of Viagra may decrease with time hence these men are less likely to have a non Viagra erection as compared to earlier when they did not take Viagra. Moreover, some men with no performance problems except psychologically may take even far larger doses of the drug to satisfy their own perception of a satisfactory sexual performance.

CONCLUSION

With the facts given, the question now is, “Is it for you?” Think it over. Never rush.
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